Trifluoroethanol solvent facilitates selective N-7 methylation of purines.

نویسندگان

  • Honorine Lebraud
  • Celine Cano
  • Benoit Carbain
  • Ian R Hardcastle
  • Ross W Harrington
  • Roger J Griffin
  • Bernard T Golding
چکیده

Purines protected at N-9 by p-methoxybenzyl are methylated or ethylated in 2,2,2-trifluoroethanol at N-7 by trimethyl- or triethyl-oxonium borofluorate, respectively. Subjecting the resulting cationic species to microwave irradiation releases an N(7)-methyl- or ethyl-purine. This one-pot procedure is an efficient regiospecific method applicable to diverse substrates.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 11 11  شماره 

صفحات  -

تاریخ انتشار 2013